Sphinx31
WebMay 9, 2024 · To investigate potential off-target effects of SPHINX31 we performed a viability experiment using a matrix of concentrations of indisulam and SPHINX31 in SRPK1 knock-out clones and control cells. We noticed that there was still synergy in clone #2.1 and less in clone #2.2. WebSep 7, 2024 · SPHINX31 protected the retinal endothelial permeability barrier from diabetes-associated loss of integrity. SPHINX31 may therefore be a potential alternative and more …
Sphinx31
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WebJun 30, 2024 · SRPK1 inhibitor SPHINX31 restrained endothelial cell viability in a dose-dependent manner. Moreover, inhibition of SRPK1 using SPHINX31 and knockdown of … WebMay 9, 2024 · First, a dropout CRISPR screen identified SRPK1 loss as a synthetic lethal interaction with indisulam that can be exploited therapeutically by the SRPK1 inhibitor SPHINX31. Moreover, a CRISPR resistance screen identified components of the degradation complex that mediate resistance to indisulam: DCAF15, DDA1, and CAND1.
WebDescription: SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) IC₅₀ = 5.9 nM). It displays selectivity for SRPK1 over a panel of 50 k... 1 - 1 of 1 1 Recommended for You VWR® Microcentrifuge Tubes, Polypropylene $67.12 ~ $18,308.13 VWR® Universal Pipet Tips $77.81 ~ $325.59 VWR® Universal Pipet Tips $178.15 ~ … WebSPHINX31. SPHINX31 (SPHINX 31) is a potent, selective, ATP competitive inhibitor of Serine/arginine-protein kinase 1 (SRPK1) with IC50 of 5.9 nM, displays no significant activity against other splicing modulating kinases (CLK family, DYRK1A and DYRK2, DYRK5, SRPK-2/3, PIM1, PIM2 kinases).
WebSPHINX31 is a potent and selective SRPK1 inhibitor, with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). SPHINX31 also … WebWe knocked down SRPK1 expression in the ENKTL cell line YT by siRNA transfection and inhibited SRPK1 using inhibitors (SPHINX31 and SRPIN340) in YT cells and peripheral blood lymphocytes (PBLs) isolated from ENKTL patients to …
WebSPHINX31(SPHINX 31),CAS:1818389-84-2.SPHINX31 (SPHINX 31) is a potent, selective, ATP competitive inhibitor of Serine/arginine-protein kinase 1 (SRPK1) with IC50 of 5.9 nM, …
WebJul 2, 2024 · Sphinx31, T CELL LEUKEMIA. Sphinx31 is an SRPK1 inhibitor. STL/VRML Files luz led con sensorWebMay 11, 2024 · In addition, SPHINX31 attenuated SRSF1 phosphorylation and nuclear localization, and increased the ratio of VEGF-A 165 b/total VEGF-A proteins. Moreover, when HUVECs were grown in conditioned medium from SPHINX31-treated CCA cells, migration slowed, and tube formation decreased. The present study demonstrates that targeting … luz led cultivo indoorWebSPHINX31 is a potent and selective inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) (IC50 value of 6 nM). It inhibits SRPK1 activity and phosphorylation of serine/arginine splicing factor 1 (SRSF1), increasing expression of the anti-angiogenic VEGF-A165b splice variant in retinal pigment epithelial (RPE) cells. luz led mesita nocheWebSPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), an SRPK1 substrate, in PC3 cells (EC50 = 360 nM) and increases expression of the anti … luz led cocina bateriahttp://www.fluoroprobe.com/archives/tag/atf luz led e27WebName: SPHINX31 CAS#: 1818389-84-2 Chemical Formula: C 27 H 24 F 3 N 5 O 2 Exact Mass: 507.1882 Molecular Weight: 507.5172 Product supplied as: Powder Purity (by … luz led neonWebSPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) with IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). SPHINX31 treatment results in inhibition of SRSF1 phosphorylation at 300 nM in PC3 prostate cancer cells. luz led individual