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WebJul 15, 2024 · PubMed Abstract: The ordered assembly of tau protein into filaments characterizes several neurodegenerative diseases, which are called tauopathies. It was previously reported that, by cryo-electron microscopy, the structures of tau filaments from Alzheimer's disease 1,2 , Pick's disease 3 , chronic traumatic encephalopathy 4 and … Webinclusion morphology and cellular specificity. Thus, tauopathies may be subdivided into disorders with inclu-sions made predominantly of 3R or 4R tau or an admixture of both (Lee et al. 2001). These differences may be demonstrated by IHC using 3R- and 4R-specific antibodies and by different banding patterns seen on WebMay 25, 2010 · Inclusion of alternatively spliced exon 10 leads to the generation of 4R tau isoforms, whereas exclusion of exon 10 leads to generation of 3R tau isoforms. Tau isoforms with 0, 1, or 2 N-terminal inserts are generated by alternative splicing of exons 2 … bing gpt new york times